Ultima Aromasin / Exemestane

Ultima Aromasin

Manufacturer: Ultima Pharmaceuticals

Category:  Oral

Dose and quantity: 25mg/pill

Package: 50 pills

Form:  Oral

Active Substance: Exemestane

Active Half-Life: 9 hours

Classification: Steroidal Aromastase Inhibitor 

Dosage: 12,5-25 mg a day

Water retention: No

Aromatization: No

Info: Ultima-Aromasin is a recently developed and potent medication that effectively combats estrogen in the body by inhibiting the conversion of certain molecules. It finds application in clinical settings for treating post-menopausal breast cancer patients who have not responded to other treatments. Unlike estrogen production in premenopausal women, which mainly occurs in the ovaries, post-menopausal estrogen production takes place in various body locations. Additionally, Ultima-Aromasin has gained popularity within the bodybuilding community due to its ability to counteract the conversion of steroids into estrogen in the body's tissues.
 

Effects

Estrogen Reduction: Ultima-Aromasin is classified as an aromatase inhibitor, which means it reduces the conversion of androgens (male hormones) into estrogen. In bodybuilding, this is particularly useful for individuals using anabolic steroids or performance-enhancing drugs. Many of these substances can lead to an excess of estrogen in the body, which can result in unwanted side effects like gynecomastia (breast tissue growth in men), water retention, and fat gain.

Muscle Definition: By reducing water retention and fat buildup caused by excess estrogen, Ultima-Aromasin can help bodybuilders achieve a leaner, more defined physique. Excess estrogen can mask muscle definition, making it harder for bodybuilders to showcase their hard-earned muscle mass.

Testosterone Enhancement: Ultima-Aromasin can lead to an increase in testosterone levels, which is a desirable outcome for bodybuilders. Higher testosterone levels are associated with muscle growth, strength gains, and improved overall performance.

Post-Cycle Therapy (PCT): While Ultima-Aromasin is often used during a steroid cycle to control estrogen, it is not typically part of post-cycle therapy. After discontinuing steroid use, bodybuilders often use other medications like SERMs (Selective Estrogen Receptor Modulators) to help restore the body's natural hormone balance.
 

Adverse Effects

Hot Flashes: Hot flashes are a common side effect of Ultima-Aromasin. They involve sudden sensations of warmth, flushing, and sweating, often concentrated in the upper body and face. These can be uncomfortable and disruptive to daily life.

Upset Stomach: Gastrointestinal symptoms such as nausea, vomiting, and diarrhea can occur with Ultima-Aromasin use. These symptoms can vary in intensity and may require management.

Joint and Muscle Pain: Ultima-Aromasin can cause joint and muscle pain, a side effect known as arthralgia and myalgia. This pain can be mild to moderate but may impact a person's quality of life, especially if it persists.

Bone Health Issues: Long-term use of Ultima-Aromasin can lead to decreased bone mineral density, increasing the risk of osteoporosis and fractures. Monitoring and management of bone health are essential, especially in postmenopausal women who are already at risk for bone-related issues.

Increased Risk of Cardiovascular Disease: There is some evidence to suggest that Ultima-Aromasin use may increase the risk of cardiovascular problems, including heart disease. This is a concern, especially for individuals with preexisting cardiovascular risk factors.

Birth Defects: Ultima-Aromasin should not be used during pregnancy, as it can lead to birth defects in the developing fetus. Women of childbearing potential should use effective contraception while taking Ultima-Aromasin and for some time after discontinuation.

Liver Function: In rare cases, Ultima-Aromasin can affect liver function, leading to abnormal liver enzyme levels. Regular monitoring of liver function is typically recommended during treatment.

Mood Changes: Some individuals may experience mood changes, including depression and anxiety, while taking Ultima-Aromasin. 

Allergic Reactions: Although rare, allergic reactions to Ultima-Aromasin can occur. Signs of an allergic reaction may include rash, itching, swelling of the face or throat, severe dizziness, or difficulty breathing.

Fatigue: Fatigue and weakness are reported side effects of Ultima-Aromasin. These symptoms can vary in severity and may impact a person's daily activities.
 

Dosage and Duration

The recommended dosage to prevent estrogen buildup ranges from 12.5 mg to 25 mg per day. Ultima-Aromasin is one of the most potent anti-estrogen drugs available, with studies indicating that it can reduce estrogen levels by as much as 85% in women. 

Typically, treatment with Aromasin is recommended for a period of 5 years in postmenopausal women with early-stage hormone receptor-positive breast cancer. 
 

Combination with Other Drugs

Combining Ultima-Aromasin (Exemestane) can be with Adjuvant Therapy for Breast Cancer, Chemotherapy, Sequential Hormone Therapy, Targeted Therapies, Bone Health Medications, Pain Management and Supportive Care.