Posted 2023-03-09
The use of drugs to enhance athletic performance dates back to ancient times, when Greek wrestlers ate large amounts of lamb to increase their strength, Scandinavian knights ate mushrooms to induce a psychotic state, and long-distance runners ate sesame seeds to boost their endurance. The term "doping" was first used in the late 19th century to refer to a combination of opium, which was used by horse racers to increase their performance. In 1865, the use of stimulants by athletes during competitions was officially documented, and in 1869, cyclists were found to be taking a heroin-cocaine mixture known as "speedball". In 1886, a cyclist's death was attributed to the use of cocaine and strychnine. Anabolic androgenic steroids, originally developed to treat testosterone deficiency, are now widely used by athletes of all levels.
Since then, the use of chemicals to artificially improve performance in sporting events has been referred to as doping. The most comprehensive definition of doping is that provided by the World Conference on Sports Medicine in Strasbourg in 1965. Doping is defined as the introduction of any material that is foreign to the body, any physiological substance in excessive proportions, or any substance used in an unnatural manner into the body of a person with the intention of artificially increasing that person's performance in competition.
Male hormone testosterone, an anabolic androgenic stimulant, has long been viewed as a representation of male strength and power. The strength hormone was the subject of studies in 1849 by Adolf Berthold, a German professor at the University of Göttingen, and in 1889 by Charles-Edouard Braun-Secard, a French neurologist and physiologist.
Three pharmaceutical companies battled to be the first to formulate the active component of the testis in a purely chemical form in the 1930s. Although there was a four-month gap between them, the synchronicity of the acts of scientists in completely distinct study organizations is remains remarkable today. Each scientific team arrived at the finish line virtually simultaneously.
It was successful to find the elixir of life. The first guy who did it on May 27, 1935, was Ernst Laqueur (Ernst Laqueur), a professor of pharmacology in Amsterdam, who created a crystalline version of the male hormone, dubbing it "testosterone".
Adolf Butenandt, a chemist, isolated a testosterone breakdown product from tens of thousands of liters of police officers' urine collected by Shering (Berlin) in 1923. (later called androsterone).
The process of obtaining testosterone turned out to be rather complex, so Butenandt created a more profitable way of synthesizing testosterone from cholesterol. After August 1935, a description of his procedure and the structure of testosterone was published in the Journal of Physiological Chemistry.
A little later is the announcement in the Swiss Journal of Chemical that Yugoslavian chemist Leopold Ruzicka, who worked at Ciba in Zurich, had been granted a patent for his method of producing testosterone from cholesterol. In 1939, Ruzicka and Butenant were awarded the Nobel Prize for their contributions to science. Many testosterone formulations entered clinical use throughout the course of the following two years. It quickly became apparent that the acquired substance (substance) cannot be taken orally in its pure form due to its oily nature, which makes it poorly soluble in water.For this reason, testosterone propionate (a testosterone ester of propionic acid) was gradually created and administered into the blood.
The resulting medication has gained the most popularity in medical practice, and injections of it had a significant impact on restoring the two key aspects of a man: vitality and sexual drive.
In the 1940s, it is said that the Soviet Union and other nations, including East Germany, were the first to investigate the use of testosterone to enhance physical performance.
They started off treating their Olympic weightlifters with testosterone. The usage of estrogen seemed to be effective in the beginning, despite some negative effects. So, it was only natural that the US wanted a piece of the action.
Team physician for the US Olympic team John Ziegler collaborated with chemists to create a medication that had comparable performance-enhancing properties without the androgenic adverse effects. The substance was methandrostenolone, later marketed as Dianabol by Ciba Pharmaceuticals and currently one of the most popular anabolic steroids on the planet. It's interesting that Arnold Schwarzenegger acknowledged using steroids while he was Mr. Olympia because they weren't prohibited at the time. Dianabol is the first anabolic steroid he mentions in the interview.
In 1958, the Food and Drug Administration (FDA) authorized the use of dianabol. It was intended to be used as a medical intervention and with older populations.
But as you can expect, it didn't take long for athletes and bodybuilders like Arnold to learn about its potential and start using it off the record. Ziegler initially administered relatively small amounts to the athletes under his watch, but it soon became apparent that those abusing Dianabol began to experience enlarged prostates and shrinking testicles (atrophy). Steroids were not outlawed by regulatory organizations for a very long period, despite the existence of proof of harmful side effects. Not until 1976 did the IOC forbid them.
As practically all anabolic steroids have a strong androgenic effect, scientists have not been able to create testosterone derivatives, which would promote tissue growth and prevent the development of secondary sexual traits.
In order to create testosterone preparations that are taken more slowly by the body and hence extend their anabolic impact, pharmacists intentionally changed the endogenous (natural) testosterone molecule (prolonging the action of the drug).
The medicine must be "retained" (deposited) in the patient's body and go through the bloodstream multiple times before being expelled from the body with the urine and other natural secretions in order to have an impact on muscle tissue and endurance mechanisms during physical activity.
Strength (training, balanced nutrition), increasing the number of contractile fibers in muscle tissues; fat loss (metabolism); endurance (increased number of mitochondria, increased oxygen consumption); blood supply to muscles (accelerated blood flow in microvessels); prevention of muscle fiber decay (intensity of training); and recovery from injuries are among the positive effects of taking anabolic steroids (synthesis of protein molecules).
In the modern world, where everything can be reached with the click of your finger the consumers have ability to access this medication without much of a problem. Yet, as easy it is, there is a major risk of buying low quality product. Therefore, you should always purchase only the high quality, genuine products from a reliable merchant. Hilma Biocare, Beligas pharmaceuticals, Euro-pharmacies and Somatrop-lab are one of the well recognized manufacturers in the world today who provide you with opportunity to check the legitimacy of products you buy on their website. You can also check the list of the certified suppliers and be sure that you are buying only the best products for best results.
History behind body enchanement.
The use of drugs to enhance athletic performance dates back to ancient times, when Greek wrestlers ate large amounts of lamb to increase their strength, Scandinavian knights ate mushrooms to induce a psychotic state, and long-distance runners ate sesame seeds to boost their endurance. The term "doping" was first used in the late 19th century to refer to a combination of opium, which was used by horse racers to increase their performance. In 1865, the use of stimulants by athletes during competitions was officially documented, and in 1869, cyclists were found to be taking a heroin-cocaine mixture known as "speedball". In 1886, a cyclist's death was attributed to the use of cocaine and strychnine. Anabolic androgenic steroids, originally developed to treat testosterone deficiency, are now widely used by athletes of all levels.
Since then, the use of chemicals to artificially improve performance in sporting events has been referred to as doping. The most comprehensive definition of doping is that provided by the World Conference on Sports Medicine in Strasbourg in 1965. Doping is defined as the introduction of any material that is foreign to the body, any physiological substance in excessive proportions, or any substance used in an unnatural manner into the body of a person with the intention of artificially increasing that person's performance in competition.
Male hormone testosterone, an anabolic androgenic stimulant, has long been viewed as a representation of male strength and power. The strength hormone was the subject of studies in 1849 by Adolf Berthold, a German professor at the University of Göttingen, and in 1889 by Charles-Edouard Braun-Secard, a French neurologist and physiologist.
First Explorers
Three pharmaceutical companies battled to be the first to formulate the active component of the testis in a purely chemical form in the 1930s. Although there was a four-month gap between them, the synchronicity of the acts of scientists in completely distinct study organizations is remains remarkable today. Each scientific team arrived at the finish line virtually simultaneously.It was successful to find the elixir of life. The first guy who did it on May 27, 1935, was Ernst Laqueur (Ernst Laqueur), a professor of pharmacology in Amsterdam, who created a crystalline version of the male hormone, dubbing it "testosterone".
Adolf Butenandt, a chemist, isolated a testosterone breakdown product from tens of thousands of liters of police officers' urine collected by Shering (Berlin) in 1923. (later called androsterone).
The process of obtaining testosterone turned out to be rather complex, so Butenandt created a more profitable way of synthesizing testosterone from cholesterol. After August 1935, a description of his procedure and the structure of testosterone was published in the Journal of Physiological Chemistry.
A little later is the announcement in the Swiss Journal of Chemical that Yugoslavian chemist Leopold Ruzicka, who worked at Ciba in Zurich, had been granted a patent for his method of producing testosterone from cholesterol. In 1939, Ruzicka and Butenant were awarded the Nobel Prize for their contributions to science. Many testosterone formulations entered clinical use throughout the course of the following two years. It quickly became apparent that the acquired substance (substance) cannot be taken orally in its pure form due to its oily nature, which makes it poorly soluble in water.For this reason, testosterone propionate (a testosterone ester of propionic acid) was gradually created and administered into the blood.
The resulting medication has gained the most popularity in medical practice, and injections of it had a significant impact on restoring the two key aspects of a man: vitality and sexual drive.
In the 1940s, it is said that the Soviet Union and other nations, including East Germany, were the first to investigate the use of testosterone to enhance physical performance.
They started off treating their Olympic weightlifters with testosterone. The usage of estrogen seemed to be effective in the beginning, despite some negative effects. So, it was only natural that the US wanted a piece of the action.
Team physician for the US Olympic team John Ziegler collaborated with chemists to create a medication that had comparable performance-enhancing properties without the androgenic adverse effects. The substance was methandrostenolone, later marketed as Dianabol by Ciba Pharmaceuticals and currently one of the most popular anabolic steroids on the planet. It's interesting that Arnold Schwarzenegger acknowledged using steroids while he was Mr. Olympia because they weren't prohibited at the time. Dianabol is the first anabolic steroid he mentions in the interview.
In 1958, the Food and Drug Administration (FDA) authorized the use of dianabol. It was intended to be used as a medical intervention and with older populations.
But as you can expect, it didn't take long for athletes and bodybuilders like Arnold to learn about its potential and start using it off the record. Ziegler initially administered relatively small amounts to the athletes under his watch, but it soon became apparent that those abusing Dianabol began to experience enlarged prostates and shrinking testicles (atrophy). Steroids were not outlawed by regulatory organizations for a very long period, despite the existence of proof of harmful side effects. Not until 1976 did the IOC forbid them.
Benefits of steroid use
The increased growth of muscular tissue is the main cause of the anabolic effect.As practically all anabolic steroids have a strong androgenic effect, scientists have not been able to create testosterone derivatives, which would promote tissue growth and prevent the development of secondary sexual traits.
In order to create testosterone preparations that are taken more slowly by the body and hence extend their anabolic impact, pharmacists intentionally changed the endogenous (natural) testosterone molecule (prolonging the action of the drug).
The medicine must be "retained" (deposited) in the patient's body and go through the bloodstream multiple times before being expelled from the body with the urine and other natural secretions in order to have an impact on muscle tissue and endurance mechanisms during physical activity.
Strength (training, balanced nutrition), increasing the number of contractile fibers in muscle tissues; fat loss (metabolism); endurance (increased number of mitochondria, increased oxygen consumption); blood supply to muscles (accelerated blood flow in microvessels); prevention of muscle fiber decay (intensity of training); and recovery from injuries are among the positive effects of taking anabolic steroids (synthesis of protein molecules).
In the modern world, where everything can be reached with the click of your finger the consumers have ability to access this medication without much of a problem. Yet, as easy it is, there is a major risk of buying low quality product. Therefore, you should always purchase only the high quality, genuine products from a reliable merchant. Hilma Biocare, Beligas pharmaceuticals, Euro-pharmacies and Somatrop-lab are one of the well recognized manufacturers in the world today who provide you with opportunity to check the legitimacy of products you buy on their website. You can also check the list of the certified suppliers and be sure that you are buying only the best products for best results.