Sibutramine

Sibutramine

Manufacturer: Unique Pharma

Category: Oral

Dose and quantity: 10 mg/ml

Package: 100 pills

Form: Oral

Active Substance: Sibutramine

Active Half-Life: 1-1,5 hours

Classification: serotonin-norepinephrine reuptake inhibitors (SNRIs)

Dosage: 10-70 mg a week

Water retention: No

Aromatization: No

Info: Sibutramine is a medication that was formerly used as an appetite suppressant for weight loss. It acts by affecting neurotransmitters in the brain, primarily serotonin and norepinephrine, to reduce appetite and promote a feeling of fullness. However, it has been withdrawn from the market in many countries due to safety concerns, particularly related to cardiovascular risks.
 

Effects:

Appetite Suppression: Sibutramine worked by influencing the levels of serotonin and norepinephrine in the brain, which could lead to reduced feelings of hunger and increased feelings of fullness, making it easier for individuals to consume fewer calories.

Weight Loss: Sibutramine could lead to modest weight loss in some individuals by helping to control their food intake and calorie consumption.

Improved Weight Management: Sibutramine could be beneficial for individuals struggling with obesity or weight-related health conditions, as it might aid in their efforts to lose weight and maintain a healthier weight.
 

Adverse Effects:

Cardiovascular Effects: Sibutramine had a significant impact on cardiovascular health. It could lead to increased blood pressure, heart rate, and the risk of arrhythmias (irregular heartbeats). This was particularly concerning for individuals with pre-existing cardiovascular conditions.

Increased Risk of Heart Attack and Stroke: Due to its effects on blood pressure and heart rate, Sibutramine use was associated with an increased risk of heart attacks and strokes, which are serious and potentially life-threatening conditions.

Nervous System Effects: Sibutramine could cause symptoms such as dizziness, headache, and insomnia. Some individuals also reported feelings of restlessness and anxiety.

Gastrointestinal Effects: Users might experience dry mouth, constipation, and nausea while taking Sibutramine.

Psychiatric Effects: Sibutramine could potentially exacerbate underlying mental health conditions or lead to mood changes, including feelings of depression or irritability.

Interactions with Other Medications: Sibutramine could interact with other medications, potentially causing harmful effects or reducing the efficacy of other treatments.

Withdrawal Symptoms: Discontinuing Sibutramine could lead to withdrawal symptoms, including fatigue, depression, and changes in mood.
 

Dosage and Duration:

Sibutramine was typically prescribed in the form of oral capsules. The common dosage was 10mg once daily. It was generally recommended to take the medication in the morning, with or without food. Dosage adjustments might have been made based on an individual's response to the medication and their medical history.

As for the duration of Sibutramine use, it was usually not intended for long-term use. Treatment durations could vary depending on the individual's weight loss goals and response to the medication. In many cases, treatment was recommended for a few weeks to a few months. Prolonged use of Sibutramine was discouraged due to the associated risks, particularly cardiovascular risks.